• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The present invention discloses a phantom for the detection of functional magnetic resonance imaging quality and a method of detection. The phantom comprises two independent shells which are movably connected to one another, wherein a blood oxygen level-dependent simulation signal module, BOLD, is disposed in the first shell, and a detection module basic images is arranged in the second shell; the BOLD simulation signal module comprises a positioning accuracy test component and a BOLD signal simulation component, the positioning precision test component comprising two cross-positioning blocks, a corner composed of blocks of isosceles right triangles being disposed on the positioning blocks, and the BOLD signal simulation component comprises an artificial brain for functional magnetic resonance imaging. The present invention can simulate BOLD signal changes of the human body and simulate an activation region of the brain by a magnetic resonance system. The present invention enables test analysis and research on the accuracy, reliability, and repeatability of brain function imaging.
    公开号:BE1025181B1
    申请号:E2017/5678
    申请日:2017-09-23
    公开日:2018-11-29
    发明作者:Jianfeng Qiu；Guozhu Wang
    申请人:Taishan Medical University；
    IPC主号:
    专利说明:

    Phantom for detecting the quality of functional magnetic resonance imaging and detection method
    Field of the invention
    The present invention relates to a phantom for detecting the quality of functional magnetic resonance imaging and a detection method, and relates, in particular, to a phantom for detecting the quality of magnetic resonance imaging for imaging of functioning of the brain (task state) based on signals dependent on the level of blood oxygen (“BOLD”), and relates specifically to an imaging model to simulate changes in BOLD signal of the human body and simulate a region activation of the brain by a magnetic resonance system for the analysis of tests and research on the accuracy, reliability and repeatability of brain functioning imagery.
    Technological background of the invention
    Magnetic resonance imaging of the brain is based on the BOLD phenomenon. The variation (functional magnetic resonance of the task state) of signal T2 * (real relaxation time T2) between the image of the section of the brain of the task state and the image of the section of the brain Static status is usually detected by rapid scanning of imaging sequences, and a corresponding stimulated brain operating region is determined through image processing and statistical analysis. Since the BOLD signal comes out for an extremely short time (3-6 ms), the region of brain functioning cannot be checked by the anatomical reference standard. As a result, the accuracy and repeatability of brain function imagery has always been low, and the results of brain function analysis have always been controversial. Therefore, a simulated bold signal is required, and the calibration of the imaging results and the verification of the analysis results of the brain's operating region and brain connections are performed in coordination with a reference standard of magnetic resonance imaging of brain functioning (imaging and data analysis).
    Summary of the invention
    2017/5678
    BE2017 / 5678
    In order to solve the above-mentioned problem, the invention provides a phantom for detecting the quality of functional magnetic resonance imaging and a detection method, and the present invention has the following features: (1) it gives the appearance of the brain, and the degree of morphological simulation by magnetic resonance imaging is high; (2) the uniformity of a magnetic field is disturbed by an external current to form a BOLD simulation module with modifications of signal region T2 * (improvement); (3) it has modules for resolution, signal / noise ratio, geometric distortion and other basic magnetic resonance imaging detection modules, which offer detection versatility; and (4) the phantom is equipped with an external programmable power control device, which can remotely control the switching on or off of the current, the duration and the pulse frequency of the external BOLD simulation modules. . The control solution can be combined with the rapid sequence of functional magnetic resonance imaging to establish a stimulation solution.
    In order to achieve the above objective, the present invention adopts the following technical solution:
    Phantom for detecting the quality of functional magnetic resonance imaging comprising two independent shells which are movably connected to each other, in which a simulation signal module depending on the level of blood oxygen, BOLD, is disposed in the first shell, and a base image detection module is disposed in the second shell;
    the BOLD simulation signal module includes a positioning accuracy testing component and a BOLD signal simulation component, wherein the positioning accuracy testing component includes two positioning blocks placed crosswise, one passage in a wedge shape composed of blocks of isosceles right triangles being disposed on the positioning blocks, and the BOLD signal simulation component includes an artificial brain for functional magnetic resonance imaging; and the basic image detection module comprises a positioning accuracy test component, a geometric distortion test component, a high contrast component and a layer deviation measurement component, which are independent of the one from the other, in which the geometric distortion test component is made up
    2017/5678
    BE2017 / 5678 of a multilayer grid type structure to simulate the degrees of geometric distortion of the images in each direction; the high contrast component comprises a substrate and a plurality of rows of through holes with different openings formed in the substrate; and the layer deviation measurement component comprises a bottom layer and two orthogonal gaps formed on the bottom layer.
    Preferably, the first shell and the second shell are cylindrical shells of organic glass, the two shells having the same diameter, and the height of the first shell is greater than that of the second shell.
    Preferably, bayonets are formed on the outer sides of the first shell and the second shell at the same time, and the two shells are connected together by the bayonets.
    Preferably, the first shell and the second shell are filled with a standard reference solution for magnetic resonance, for example copper sulphate, distilled water, sodium chloride or nickel chloride.
    Preferably, the geometric distortion test component comprises several layers of grids, the control opening of each grid being the same, and the thicknesses of the sides of the controls being identical, the distance between the vertices of two arbitrary controls is measured on the image obtained by scanning each layer, the distance being compared to the real distance to obtain the degree of geometric distortion of the image in the axial direction, and the distances between the vertices of the controls of different layers are measured to obtain the geometric distortion in a sagittal direction and a radicular direction.
    Preferably, the grids are made of PVC material, and three layers of grids are provided.
    Preferably, multiple rows of through holes of different diameters are formed on the substrate of the high contrast component, multiple through holes being formed in each row, the diameters of the through holes on the same row having the same size, the intervals between the neighboring through orifices having the same diameters are equal to their diameters, images of the through orifices are observed on the image obtained by scanning, and if the orifices having the same diameters are clear and if the signals are not interconnected, the minimum opening satisfying the condition is a limit visual width.
    2017/5678
    BE2017 / 5678 Preferably, the corner shapes on the positioning blocks of the positioning precision test component are crosswise arranged, a positioning line is arranged at the intersection of the long sides of the two positioning blocks, if the lengths of long, dark black bands formed on the image obtained by scanning are equal, this indicates that the positioning is correct otherwise, there is a positioning deviation.
    Preferably, gaps having an angle of 45 degrees are formed on the bottom layer of the layer deviation measurement component, the gaps being orthogonal, the widths of the gaps being identical, and an actual layer thickness is calculated and confirmed by a signal formed by the two gaps in the image obtained by scanning to obtain a deviation in the thickness of the configuration layer.
    Preferably, a setting region in the second shell is scanned to obtain the signal, noise and variance value of the region, and the signal-to-noise ratio of the image is calculated.
    Preferably, the artificial brain, in the form of the BOLD signal simulation component, consists of a hydrogel containing from 0.5 to 1% of copper sulphate, from 0.3 to 0.5% of sodium chloride, 1 to 1.25% agarose, 0.100 to 0.125% Gd-DTPA (gadolinium diethylene triamine pentaacetic acid) and is used to simulate Tl and T2 relaxation values of a gray matter from a human brain under magnetic resonance.
    Preferably, the artificial brain has the structural shape of a human brain, and has a cerebellum, a ventricle and a gyrus. The morphological data of the artificial brain comes from the International Consortium for Brain Mapping (“ICBM” for International Consortium for Brain Mapping) of the Montreal Neurological Institute, and it is a three-dimensional reference brain matrix integrating 152 real brains, the digital brain outline being obtained by 3D printing, then a material is filled to form an artificial brain entity.
    Preferably, a hollow cavity is disposed respectively on a position of the frontal lobe and on a position of the hippocampus of the artificial brain corresponding to the direction of short transverse axis of the first shell, and is distant from the surface of the gyrus by 1 cm and 5 cm respectively, and is used to simulate BOLD signals from the frontal lobe region and the hippocampus region (the hippocampus and the amygdaloid nucleus having weaker BOLD signals) and to simulate cognitive functional regions
    2017/5678
    BE2017 / 5678 of the human brain. A hollow cavity is disposed respectively at a position of the cingulate gyrus of the artificial brain corresponding to the longitudinal direction of the long axial line of the first shell, and is distant from the surface of the gyrus by 3 cm and is used to simulate the bold signals of the cingulate gyrus of the human brain.
    Preferably, a loop extends from the first shell along the direction of the longitudinal axial line of the first shell and is connected to an external supply control device by a connecting line.
    Preferably, the external power control device is a programmable control device, and controls the start, duration or stop between the power supply and the loops and, simultaneously, controls the time, duration and the on / off control frequency.
    A detection method based on the above detection ghost comprises the following steps:
    during conventional scanning of the artificial brain component, all three loops are in an extinct state, and the water molecules in the hollow cavities and the water molecules in the gel are all in a normal state of signal imaging by magnetic resonance ;
    while the task status is being scanned, turn on or off the external power controller according to the set pulse frequency in cooperation with a scan sequence so as to generate a pulse current at through the loops in the corresponding hollow cavities, and modify the uniformity of a local magnetic field at the level of the water molecules in the hollow cavities to cause a modification in duration; and implementing an alternative and continuous event of a signal difference between the conventional scanning and the scanning of the task state to carry out the bold signals of the artificial brain, and carrying out the extraction of the outline of the brain on an image of a sequence obtained by magnetic resonance of the functioning of the brain.
    The present invention has the following beneficial effects:
    (1) the present invention provides an imaging model to simulate changes in the BOLD signal of the human body and to simulate the region of activation of the brain by the magnetic resonance system for analysis of trials and research on accuracy, reliability and repeatability of brain function imagery;
    2017/5678
    BE2017 / 5678 (2) the present invention can be integrated into reference tests of magnetic resonance imaging of the functioning of the brain (imaging and data analysis) to perform the calibration of imaging results and the verification of results of analysis of regions of brain function and brain connections;
    (3) the present invention gives an aspect of the brain, the degree of morphological simulation of magnetic resonance imaging being high, the uniformity of the magnetic field is disturbed by an external current to form modifications of the T2 * signal region;
    (4) the present invention provides resolution, geometric distortion, signal-to-noise ratio and other basic magnetic resonance imaging detection modules, and provides detection versatility; and (5) the present invention makes it possible to remotely control the on / off control of the current, the duration, the pulse frequency of the BOLD external simulation modules, in order to effectively guarantee the health and safety of the body of an experimenter. in simulation.
    Brief description of the figures
    Fig. 1 is an external view of the overall combination of a ghost of the present invention;
    Fig. 2 is a schematic diagram of a geometric distortion test component of the present invention;
    Fig. 3 is a schematic diagram of a high contrast test component of the present invention;
    Fig. 4 (a) is a side view of a layer deviation measurement component of the present invention;
    Fig. 4 (b) is a front view of the layer deviation measurement component of the present invention;
    Fig. 5 is a schematic diagram of a shape of a loop in a rectangular space of an artificial brain of the present invention;
    Fig. 6 is a schematic diagram of the connection and use positions of the phantom of the present invention and of an external power control device.
    2017/5678
    BE2017 / 5678 Detailed description of the embodiments
    The present invention is further illustrated below in combination with the following drawings and embodiments.
    As shown in Fig. 1, a quality control and detection phantom adapted to brain imaging by medical functional magnetic resonance and simulating BOLD signal modifications includes a global structure which can be combined and detachable (profile module (or contour) which can be combined and detachable), a BOLD simulation signal module and a basic image detection module.
    The combinable and detachable profile module comprises a cylindrical shell made of organic poly (methyl methacrylate) (PMMA) glass 18 cm in diameter, and the shell is divided into two parts having heights of 15 cm and 5 cm. The two parts are combinable and detachable, and their internal parts do not communicate with each other. The 15 cm high cylinder contains the BOLD simulation signal module, one end being sealed, and the other end being connected to an external power controller via a conductive cable. Two ends of the cylinder with a height of 5 cm are sealed, and they can contain modules of resolution, geometric distortion, signal / noise ratio and other parameters detection parameters by basic imagery, and the cylinders are filled with a standard reference solution for magnetic resonance (copper sulphate, distilled water, sodium chloride / nickel chloride). The two cylinders can be combined via bayonets.
    The BOLD simulation signal module and the basic image detection module contain square stud structures made of PMMA material at both ends, and the connection and separation of the two modules of the phantom is achieved by the connection and the opening of stud structures. The two phantom modules can be combined for use (scanning / scanning) and can also be used independently.
    The basic image detection module contains 5 independent test components, which are respectively as follows:
    (1) A geometric distortion test component consists of a rectangular matrix, in which the component consists of three layers of grids made of PVC material. The opening of each grid control is 3 * 3 * 3 mm 3 , and the thickness of the
    2017/5678
    BE2017 / 5678 PVC side of the control block is 1 mm. The distance between the vertices of two arbitrary controls is measured on the image obtained by scanning the layer, and the distance is compared with the actual distance to obtain the degree of geometric distortion of the image in the axial direction. The grids are divided into three layers up and down, the thickness of PVC between the layers being 1 mm, and the distances between the vertices of the controls of the different layers are measured to obtain the geometric distortion in a sagittal direction and a root direction, as illustrated in FIG. 2.
    (2) A high contrast component (limiting resolution) is composed of through holes of different diameters, 5 rows of through holes of different diameters are formed on a PMMA substrate, the openings being 5 mm, 2.5 mm , 1 mm, 0.5 mm and 0.2 mm, and the intervals between the through holes having the same diameters are equal to their diameters, as shown in FIG. 3. The images of orifices crossing through are observed on the image obtained by scanning the layer, and if the orifices having the same diameters are clear and if the signals are not interconnected, the minimum opening satisfying the condition is a limited visual width.
    (3) A positioning accuracy test component is composed of blocks of isosceles right-angled triangles in a wedge shape, in which two isosceles right triangles are placed crosswise, as shown in Fig. 4. When the layer is scanned, a positioning line is placed at the intersection of the long sides of the two blocks of triangles. If the positioning is correct, the lengths of the long and dark black bands formed by the blocks of triangles on the image obtained are equal. If the positioning system has a deviation, the lengths of the two long black bands are not equal.
    (4) A layer deviation measurement component is composed of strip-shaped PVC containing gaps, in which the length of a rectangular PVC block is 6 mm, the width is 6 mm, the measurement component layer deviation comprises two 45 degree gaps having widths of 1 mm, and the two gaps are orthogonal. When the layer is scanned, two symmetrically distributed light signals (caused by the standard solution filled in the gaps) occur on the image, the full widths at half the maximum of the light signals are measured, the product of the two whole widths at half the maximum is calculated, the square root of the product is calculated to obtain an actual layer thickness, and the thickness of the
    2017/5678
    BE2017 / 5678 real layer being compared to a thickness of the configuration layer to obtain a deviation of thickness of the configuration layer.
    (5) An overflow layer component containing no physical object is used to measure the signal to noise ratio, in which, when the layer is scanned, the image obtained can be used to select a region of interest, and the signal to noise ratio of the image can be calculated by obtaining the signal, the noise and a variance value.
    The BOLD simulation signal module includes a positioning accuracy test component and a BOLD signal simulation component. The structure of the positioning accuracy test component is essentially compatible with that of the basic image detection module.
    The outline of the BOLD signal simulation component is an artificial brain of 15 * 15 * 13 cm 3 . The artificial brain consists of a hydrogel containing 0.5 to 1% copper sulphate, 0.3 to 0.5% sodium chloride, 1 to 1.25% agarose, 0.100 to 0.125 % Gd-DTPA (gadolinium diethylene triamine pentaacetic acid) and is used to simulate the relaxation values T1 and T2 of a gray matter of a human brain by magnetic resonance.
    The appearance of the artificial brain is obtained by the simulation of cerebral image of reference Chinese Digital, and is approved with a standard brain ICBM. The artificial brain is shaped like a human brain, and includes a cerebellum, a ventricle and a gyrus. The proton-enriched hydrogel (H + ), and can produce light signals similar to the brightness of the human brain during magnetic resonance scanning.
    The artificial brain contains three small rectangular volume spaces, and the space is approximately 3375 mm 3 (approximately 12527 mm 3 of pixels of functional magnetic resonance images and 3 to 4 scanning levels are occupied). The space contains a circular loop with a diameter less than or equal to 2 mm, a single strand constitutes the loop, and the loop is coated with rubber and enters the space from the direction of the long axis of the ghost and enters through the space from the direction of the long axis, after a rounding of 350 degrees, as shown in Fig. 5. The loop is fixed in space, and the space is filled with a standard reference solution for magnetic resonance (pure water, copper sulphate and sodium chloride).
    The two rectangular volume spaces are located along the direction of the phantom's short axis, and are respectively located on a frontal lobe position and a position
    2017/5678
    BE2017 / 5678 from the hippocampus of the artificial brain, and are 1 cm and 5 cm away from the surface of the gyrus respectively, and are used to simulate bold signals from the frontal lobe region and the hippocampal region ( the hippocampus and the amygdaloid nucleus with weaker BOLD signals) and to simulate the cognitive functional regions of the human brain. A rectangular volume space is located in the direction of the long axis of the ghost, and is located in a cingulate gyrus position of the artificial brain, and is 3 cm away from the surface of the gyrus and is used to simulate the bold signals from the cingulate gyrus of the human brain.
    Two connection ends of the loops in the three rectangular volume spaces penetrate through the phantom and are connected to the external power control device. The length of the connection is not less than 5 m, so as to guarantee that the external supply control device can be placed on an external control console of the operating room via a plate waveguide, when the ghost is in a scanning state, as shown in Fig. 6.
    The external power control device is a programmable control device, and the start, duration or stop of the power supply is controlled by programming; and the on / off time, duration, frequency and times are fixed. The BOLD simulation module can be used for functional magnetic resonance imaging. During conventional scanning of the artificial brain component, all three loops are in an extinct state. The water molecules in the rectangular volume spaces and the water molecules in the gel are in a normal state of magnetic resonance signal imaging. While the task status is being scanned, the external power controller is turned on and off at a pulse rate set in cooperation with a scan sequence to generate a pulse current in the loops. The pulse current (the duration is not more than 6 ms) modifies the uniformity of a local magnetic field at the level of water molecules in rectangular volume spaces to cause a time change T2 *, and a 1 to 3% signal difference is generated with conventional T2 * scanning. An alternating and continuous event of the signal difference between conventional scanning and task status scanning is implemented, and the duration is not less than 6 min. Therefore, a function of simulating bold signals from the human brain is performed.
    2017/5678
    BE2017 / 5678 The external power supply control device comprises a fiber receiver, a frequency-voltage converter, a current control and a remote control loop. The external power control device can be programmed to obtain on / off switching (> 200 / s), high and low current switching (1 mA or = 0.5 mA) and simultaneous BOLD signal simulation and independent of one or more functional regions of the loops in the three volume spaces; and the sequential and independent start / stop function (the interval time being <6 ms) and the switching of high and low current of the loops in the three volume spaces can also be performed to analyze and simulate brain connections from different functional regions.
    The ghost is equipped with image post-processing software. The software can be installed on Windows series platforms and on a Linux platform. The software is used to extract the cerebral contours from the images of sequences by magnetic resonance of functioning of the brain (format .img / .dem) obtained by magnetic resonance systems of various manufacturers without modifying the formats. That is, the scalp removal operation during functional magnetic resonance image processing, and, at the same time, the excitation sequence data from the external power controller is automatically imported. conventional magnetic resonance image processing software (SPM, AFNI, FSL, etc.). Although the specific embodiments of the present invention have been described above in combination with the drawings, they do not limit the scope of protection of the present invention, and those skilled in the art should understand that various modifications or variations, which can be carried out by a person skilled in the art on the basis of the technical solutions of the present invention without any creative effort, come within the scope of the protection of the present invention.
    权利要求:
    Claims (15)
    [1]
    1. Phantom for detecting the quality of functional magnetic resonance imaging comprising two independent shells which are movably connected to each other, in which a simulation signal module depending on the level of blood oxygen, BOLD, is arranged in the first shell, and a basic image detection module is arranged in the second shell;
    the BOLD simulation signal module includes a positioning accuracy testing component and a BOLD signal simulation component, wherein the positioning accuracy testing component includes two positioning blocks placed crosswise, one passage in a wedge shape composed of blocks of isosceles right triangles being disposed on the positioning blocks, and the BOLD signal simulation component includes an artificial brain for functional magnetic resonance imaging; and the basic image detection module comprises a positioning accuracy test component, a geometric distortion test component, a high contrast component and a layer deviation measurement component, which are independent of the one from the other, and wherein the geometric distortion test component consists of a multilayer grid-like structure for simulating the degrees of geometric distortion of the images in various directions; the high contrast component comprises a substrate and a plurality of rows of through holes with different openings formed in the substrate; and the layer deviation measurement component comprises a bottom layer and two orthogonal gaps formed on the bottom layer.
    [2]
    2. A phantom for detecting the quality of functional magnetic resonance imaging according to claim 1, in which the first shell and the second shell are cylindrical shells of organic glass, the two shells having the same diameter, and the height of the first shell is greater than that of the second shell.
    [3]
    The phantom for detecting the quality of functional magnetic resonance imaging according to claim 1, wherein bayonets are formed on the outer sides of the first shell and the second shell at the same time, and the two shells are connected. together by bayonets.
    2017/5678
    BE2017 / 5678
    [4]
    4. A phantom for detecting the quality of functional magnetic resonance imaging according to claim 1, in which the geometric distortion test component comprises several layers of grids, the control opening of each grid being the same, and the thicknesses of the sides of the controls being identical, the distance between the vertices of two arbitrary controls is measured on the image obtained by scanning each layer, the distance being compared with the real distance to obtain the degree of geometric distortion of the image according to the axial direction, and the distances between the vertices of the controls of different layers are measured to obtain the geometric distortion in a sagittal direction and a root direction.
    [5]
    5. A phantom for detecting the quality of functional magnetic resonance imaging according to claim 4, in which the grids are made of a PVC material, and three layers of grids are provided.
    [6]
    6. A phantom for the detection of the quality of functional magnetic resonance imaging according to claim 1, in which multiple rows of through holes of different diameters are formed on the substrate of the high contrast component, several through holes being formed on each row, the diameters of the through orifices on the same row having the same size, the intervals between the through orifices having the same diameters are equal to their diameters, images of the through orifices are observed on the image obtained by scanning, and if the orifices having the same diameters are clear and if the signals are not interconnected, the minimum opening satisfying the condition is a limit visual width.
    [7]
    7. A phantom for detecting the quality of functional magnetic resonance imaging according to claim 1, wherein the wedge shapes on the positioning blocks of the positioning accuracy test component are crosswise arranged, a line of positioning is arranged at the intersection of the long sides of the two positioning blocks, if the lengths of long, dark black bands formed on the image obtained by scanning are equal, this indicates that the positioning is correct otherwise, there is a difference of positioning.
    [8]
    8. A phantom for detecting the quality of functional magnetic resonance imaging according to claim 1, in which gaps having an angle of 45
    2017/5678
    BE2017 / 5678 degrees are formed on the lower layer of the layer deviation measurement component, the gaps being orthogonal, the widths of the gaps being identical, and an actual layer thickness is calculated and confirmed by a signal formed by the two gaps of the image obtained by scanning, to obtain a deviation in thickness from the configuration layer.
    [9]
    9. A phantom for detecting the quality of functional magnetic resonance imaging according to claim 1, in which a setting region in the second shell is scanned to obtain the signal, the noise and the variance value of the region, and the signal-to-noise ratio of the image is calculated.
    [10]
    The phantom for detecting the quality of functional magnetic resonance imaging according to claim 1, wherein the artificial brain, in the form of the BOLD signal simulation component, consists of hydrogel containing from 0.5 to 1 % copper sulphate, 0.3 to 0.5% sodium chloride, 1 to 1.25% agarose, 0.100 to 0.125% diethylene triamine pentaacetic acid of gadolinium (Gd-DTPA), and is used to simulate relaxation values T1 and T2 of a gray matter of a human brain under magnetic resonance.
    [11]
    11. A phantom for detecting the quality of functional magnetic resonance imaging according to claim 10, wherein the artificial brain has the structural shape of a human brain, and has a cerebellum, a ventricle and a gyrus.
    [12]
    12. A phantom for detecting the quality of functional magnetic resonance imaging according to claim 1, in which a hollow cavity is disposed respectively on a position of the frontal lobe and on a position of the hippocampus of the artificial brain corresponding to the direction. of short transverse axis of the first shell, a hollow cavity being disposed at a position of cingulate gyrus of the artificial brain corresponding to the longitudinal direction of the long axial line of the first shell, and a loop is provided on each hollow cavity.
    [13]
    13. A phantom for detecting the quality of functional magnetic resonance imaging according to claim 12, wherein a loop extends from the first shell along the direction of the longitudinal axial line of the
    2017/5678
    BE2017 / 5678 first shell and is connected to an external power control device by a connecting line.
    [14]
    14. A phantom for detecting the quality of functional magnetic resonance imaging according to claim 1, in which the external power control device is a programmable control device, and controls the start-up, the duration or the stop between the power supply and the loops and, simultaneously, control the time, duration and frequency of on / off control.
    [15]
    15. A method of detecting the detection phantom according to any one of claims 1 to 14, comprising the following steps:
    during conventional scanning of the artificial brain component, all three loops are in an extinct state, and the water molecules in the hollow cavities and the water molecules in the gel are all in a normal state of signal imaging by magnetic resonance ;
    while the task status is being scanned, turn on or off the external power controller according to the set pulse frequency in cooperation with a scan sequence so as to generate a pulse current at through the loops in the corresponding hollow cavities, and modify the uniformity of a local magnetic field at the level of the water molecules in the hollow cavities to cause a modification in duration of T2 *; and implementing an alternative and continuous event of a signal difference between the conventional scanning and the scanning of the task state to carry out the bold signals of the artificial brain, and carrying out the extraction of the outline of the brain on an image of a sequence obtained by magnetic resonance of the functioning of the brain.
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    法律状态:
    2018-12-17| FG| Patent granted|Effective date: 20181129 |
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    申请号 | 申请日 | 专利标题
    CN2016108475953|2016-09-23|
    CN201610847595.3A|CN106377261A|2016-09-23|2016-09-23|Body model for detecting quality of magnetic resonance function imaging and method|
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